
Solid form screening and selection
Solid state characterization is key to understanding the physical properties of solid materials. These physical properties can have an impact on the material’s bulk properties, formulation performance, processability, stability and appearance.
A deep understanding of the physical properties of the molecules will be useful to understand the potential challenges that that form may encounter during development or manufacturing and will feed back into the design of the active ingredients to optimize the physicochemical attributes that will make them more likely to succeed depending on their specific application.
Understanding the crystallinity behavior of the molecule, as well as its thermal properties, hygroscopicity, etc. will help us evaluate the fitness of the current form for development and will establish the basis against which different batches of material produced should be measured.
Solid state characterisation

Solid form screening and selection
Once a suitable solid form has been selected, the next step is to know how to reproducibly make this form using a robust and scalable process. As well as the polymorphic form, particle size distribution (PSD) and crystal habit are often key product attributes that affect performance or processability. Unfortunately, the PSD and crystal habit are often highly susceptible to changes as the process is developed and scaled.
Solitek can provide the key knowledge of solubility and crystallization kinetics, growth and nucleation, and how these are affected by chemical engineering factors, thereby avoiding surprises on transfer from lab to kilo-lab, pilot plant and manufacturing.
Solid form screening and selection

Crystallization process development
Solid state characterization is key to understanding the physical properties of solid materials. These physical properties can have an impact on the material’s bulk properties, formulation performance, processability, stability and appearance.
A deep understanding of the physical properties of the molecules will be useful to understand the potential challenges that that form may encounter during development or manufacturing and will feed back into the design of the active ingredients to optimize the physicochemical attributes that will make them more likely to succeed depending on their specific application.
Understanding the crystallinity behavior of the molecule, as well as its thermal properties, hygroscopicity, etc. will help us evaluate the fitness of the current form for development and will establish the basis against which different batches of material produced should be measured.
Crystallization process development

Early enabling formulation development
Through the synergy between solid state chemistry and formulation, we can add value to your pre-clinical project, while decreasing timelines. During preformulation, the physicochemical properties of the drug substance are investigated. Understanding the relevant physiochemical and biopharmaceutical properties determines the appropriate formulation and delivery method for pre-clinical and Phase 1 studies. Performed using small-scale analysis techniques, we can determine key characteristics of drug molecules even when solubility is low and drug material is limited.
Our experience and technical knowledge can rapidly identify molecule challenges with protocols which emphasize efficient use of resources. Applying our understanding of drug physicochemical properties, we can offer tailored and rational preclinical formulation development.
Using the Developability Classification System (DCS) as our framework, we examine how the physicochemical characteristic of a compound may affect oral absorption and bioavailability, determining risk and suggesting formulation strategies. Using a rapid excipient screening approach, we can provide preclinical formulations which enhance drug solubility and overcome in vivo sources of pharmacokinetic variability. In vitro testing using biorelevant models can demonstrate formulation abilities to promote supersaturation and resist unfavorable situations such as pH-mediated precipitation and food effects.
Early enabling formulation development

Training and consultancy
Our team of experts would be delighted to share their knowledge and experience with you. These services could be both theoretical and practical, and located either in Solitek’s site in Barcelona or at the customer’s choice of venue. Please contact us for more information.
Training and consultancy

Integrated drug discovery
Charnwood Molecular is an award-winning, UK-based CRO which has been providing expert drug discovery and development support for over 20 years. Clients range from virtual start-ups to established global agrochemical, materials chemistry, diagnostic, biotechnology and pharmaceutical companies. All clients benefit from a proactive and open approach, geared towards rapidly advancing projects towards important key decision points and beyond.
An expert scientific team, which enjoys the benefit of substantial and varied industrial and academic experience, focusses on providing intellectual input and enabling the rapid advancement of projects. Charnwood Molecular is a results-driven, dynamic company committed to delivering success for global clients. Their scientists seek to achieve research excellence in their work and are passionate about maintaining their market-leading status.
The expertise and service offerings span areas from customised bioassay development, computational, synthetic and medicinal chemistry to process research and development. As a team with wide-ranging experience gained within fine chemical, pharmaceutical and biotech companies, they can provide expertise at all stages of your research project, aiming for intellectual input and novelty in your programs.
Charnwood Molecular‘s portfolio of services is wide and currently includes: Customised bioassay development Medicinal Chemistry (design, synthesis and multi-parameter optimisation of drug molecules for discovery projects; computational chemistry and emerging synthetic technologies) Custom Synthesis preparation of key chemical intermediates on up to 20-litre scale Chemical Development and Process Research Services including route design, development and optimization.
Analytical Chemistry Support. For more information please visit the website: www.charnwood-molecular.com or contact the Business Development team: info@charnwood-molecular.com Our experience and technical knowledge can rapidly identify molecule challenges with protocols which emphasize efficient use of resources. Applying our understanding of drug physicochemical properties, we can offer tailored and rational preclinical formulation development.
Using the Developability Classification System (DCS) as our framework, we examine how the physicochemical characteristic of a compound may affect oral absorption and bioavailability, determining risk and suggesting formulation strategies. Using a rapid excipient screening approach, we can provide preclinical formulations which enhance drug solubility and overcome in vivo sources of pharmacokinetic variability. In vitro testing using biorelevant models can demonstrate formulation abilities to promote supersaturation and resist unfavorable situations such as pH-mediated precipitation and food effects.