Solitek offers development stage-appropiate advice to help you reduce the risk of failure during the later development stages and to maximise the returns from potential out-licensing opportunittes.

Solid state characterisation

Solid form screening and selection

Crystallization process development

Early enabling formulation development

Training and consultancy
Integrated drug discovery
Charnwood Molecular is an award-winning, UK-based CRO which has been providing expert drug discovery and development support for over 20 years. It is a results-driven, dynamic company committed to delivering success for global clients.
Clients range from virtual start-ups to established global agrochemical, materials chemistry, diagnostic, biotechnology and pharmaceutical companies. We undertake projects requiring bioscience, DMPK / ADME, medicinal, computational, and synthetic chemistry services which can vary considerably in terms of scope and deliverables.
These projects typically range from a single scientist, engaged on a short-term “proof-of-concept” research project for a new start-up business, right through to a multi-scientist, multi-year drug discovery and development collaboration with a leading global pharmaceutical or biotechnology company.
An expert scientific team, which enjoys the benefit of substantial and varied industrial and academic experience, they provide expertise at all stages of your research project, aiming for intellectual input and novelty in your programs. Their scientists seek to achieve research excellence in their work and are passionate about maintaining their market-leading status. Sharing the same laboratory space at a cutting-edge campus facility, teams across all disciplines work closely together on client projects.
Charnwood Molecular‘s portfolio of services is wide and currently includes: Integrated drug discovery from target to candidate, customised bioassay development, DMPK / ADME for analysis and insight medicinal chemistry (design, synthesis and multi-parameter optimisation of drug molecules for discovery projects), computational chemistry, custom synthesis preparation of key chemical intermediates on up to 20-litre scale, chemical development and process research including route design, development and optimization. Analytical chemistry supports all of these services.
Our experience and technical knowledge can rapidly identify molecule challenges with protocols which emphasize efficient use of resources. Applying our understanding of drug physicochemical properties, we can offer tailored and rational preclinical formulation development.
Using the Developability Classification System (DCS) as our framework, we examine how the physicochemical characteristic of a compound may affect oral absorption and bioavailability, determining risk and suggesting formulation strategies. Using a rapid excipient screening approach, we can provide preclinical formulations which enhance drug solubility and overcome in vivo sources of pharmacokinetic variability. In vitro testing using biorelevant models can demonstrate formulation abilities to promote supersaturation and resist unfavorable situations such as pH-mediated precipitation and food effects.
For more information please visit: www.charnwood-molecular.com or contact the Business Development team: info@charnwood-molecular.com