Solid Form Screening And Selection

Solid form selection plays a pivotal role in overcoming challenges associated with modern drug development:

• Improved solubility and bioavailability: Giving drugs the best chance to dissolve effectively to achieve the desired therapeutic effect. 

• Enhanced stability: Selecting solid forms resistant to environmental factors like humidity and temperature. 

• Optimized manufacturability: Streamlining the production process with solid forms that offer better flow properties and compressibility. 

• Novel IP opportunities: Identifying unique solid forms such as salts and cocrystals can lead to patentable innovations. 

Our services include the investigation and selection of the optimal solid form for the intended drug formulation, i.e. clinical or preclinical formulation, immediate or sustained release, liquid or solid oral dosage form, etc., to ensure that your product excels in quality and performance. 

We leverage cutting-edge technologies and a systematic approach to deliver precise results: 

• Polymorph Screening: Exploring a diverse range of conditions likely to be encountered in a development and manufacturing environment, to  Identify and characterize different crystalline forms to find the most stable and effective option. 

• Salt Selection: Enhancing solubility and stability by evaluating various salt forms. 

• Cocrystal Screening: Exploring multi-component systems to improve physical and chemical properties. 

• Dissolution and Solubility Testing: Ensuring optimal release profiles, including immediate release and sustained release formulations. 

• Full Solid State Characterization and Structural Analysis: Employing techniques like, XPRD, DSC and TGA to thoroughly characterize novel solid forms, and CSP or microelectron diffraction technologies to elucidate the structure of the optimal solid forms for development. 

Solid Form Screening and Selection directly impact multiple aspects of pharmaceutical development, including: 

• Formulation design: Selecting the optimal solid form to support the development of robust pharmaceutical formulations. 

• Generation of novel IP: Selection of the right solid form to extend the life cycle of the drug substance, while opening opportunities for alternative drug formulations. 

• Non-infringing solid forms: Identification of non-infringing solid forms that can be used without breaching existing patent protection. 

By identifying the most suitable solid form, we help pharmaceutical companies reduce development timelines and improve drug performance, positioning products for market success. 

At Solitek, we are committed to providing customized solutions that align with your specific goals. Our client-centric approach focuses on delivering high-quality results through collaboration and innovation: 

• Tailored strategies: Solutions adapted to your drug candidate’s unique requirements. 

• Expert insights: Decades of experience in solid form science. 

• Innovative techniques: Cutting-edge technologies to ensure precision and reliability. 

Our comprehensive services extend from discovery to market, ensuring seamless integration into your development pipeline. 

• Experience and Expertise: A proven track record of supporting successful pharmaceutical innovations. 

• Commitment to Quality: Rigorous testing and analysis for reliable and reproducible results. 

• Focus on Innovation: Constantly advancing techniques to stay ahead in solid form science. 

Partnering with Solitek ensures your drug development program benefits from state-of-the-art solid form screening and selection, paving the way for impactful and effective therapies.